Tyrosine kinase-IN-7( —— )

Catalog No. M37096 CAS No. 345615-74-9

Tyrosine kinase-IN-7 is a potent inhibitor of the tyrosine kinase EGFR, inhibiting EGFR(WT) and EGFR(T790M) and showing anti-cancer and anti-tumor activity in a variety of cancer cell lines.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

Tyrosine kinase-IN-7
Note

Research use only, not for human use.
Brief Description

Tyrosine kinase-IN-7 is a potent inhibitor of the tyrosine kinase EGFR, inhibiting EGFR(WT) and EGFR(T790M) and showing anti-cancer and anti-tumor activity in a variety of cancer cell lines.
Description

Tyrosine kinase-IN-7 (compound 13h) is an inhibitor of the tyrosine kinase EGFR. The IC50s for inhibiting EGFR(WT) and EGFR(T790M) are 0.630 μM and 0.956 μM respectively. Tyrosine kinase-IN-7 has antitumor activity against four cancer cell lines (HepG2, HCT-116, MCF-7, and A431) with IC50s of 13.02 μM, 10.14 μM, 12.68 μM, and 47.05 μM, respectively.
In Vitro

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In Vivo

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Synonyms

——
Pathway

Immunology/Inflammation
Target

Antiviral
Recptor

Antiviral | EGFR
Research Area

——
Indication

——

Chemical Information

CAS Number

345615-74-9
Formula Weight

297.38
Molecular Formula

C16H15N3OS
Purity

>98% (HPLC)
Solubility

——
SMILES

OC1=CC=C(NC2=NC=NC3=C2C2=C(CCCC2)S3)C=C1
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Elmetwally SA, et al. Design, synthesis and anticancer evaluation of thieno[2,3-d]pyrimidine derivatives as dual EGFR/HER2 inhibitors and apoptosis inducers. Bioorg Chem. 2019 Jul;88:102944.?

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